INFLUENCE OF THE HINGE REGION AND ITS ADJACENT DOMAINS ON BINDING AND SIGNALING PATTERNS OF THE THYROTROPIN AND FOLLITROPIN RECEPTOR.

Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

Glycoprotein hormone receptors (GPHR) have a large extracellular domain (ECD) divided into the leucine rich repeat (LRR) domain for binding of the glycoprotein hormones and the hinge region (HinR), which connects the LRR Nozzle domain with the transmembrane domain (TMD).Understanding of the activation mechanism of GPHRs is hindered by the unknown i

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Diagnosing the Machine Set Rotor Using Its Relative Vibrations

The efficiency and dependability of machine set depends on the quality of maintenance of functional units of the machine set rotor.Diagnosing the functional units of the machine set can significantly increase the effectiveness and efficiency of the maintenance of the machine set.The purpose of the study was to substantiate the separation of the mac

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The inference of HIV-1 transmission direction between a man who has sex with men and his heterosexual wife based on the sequences of HIV-1 quasi-species

Currently, homosexual transmission has become one of the main routes of HIV-1 spread in China.Furthermore, about 80% Chinese men, who have sex Wallet Gift Box with men (MSM), feel forced to enter eventually into heterosexual marriages due to the Chinese traditional marriage culture, which may cause HIV-1 infection in families.In this study, we iden

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