Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.
Glycoprotein hormone receptors (GPHR) have a large extracellular domain (ECD) divided into the leucine rich repeat (LRR) domain for binding of the glycoprotein hormones and the hinge region (HinR), which connects the LRR Nozzle domain with the transmembrane domain (TMD).Understanding of the activation mechanism of GPHRs is hindered by the unknown i